Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
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DOI：
10.1523/jneurosci.01-08-00876.1981
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发表时间：
1981-08
期刊：
影响因子：
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通讯作者：
G. Aston-Jones;F. Bloom
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文献类型：
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作者：
G. Aston-Jones;F. Bloom
在行为大鼠的梦游周期（S-WC）期间检查了含有去甲肾上腺素的蓝斑（NE-LC）神经元的自发放电。单单元和多单元细胞外记录产生了一组一致的特征放电特性。 (1) 强直放电与 S-WC 的阶段共同变化，在清醒时最高，在慢波睡眠期间较低，在反常睡眠期间几乎不存在。 (2) 在慢波睡眠期间释放预期的 S-WC 阶段以及阶段性皮层活动，例如纺锤波。 (3)在梳理毛发和消耗甜水期间主动醒来时放电减少。 (4) 突发的冲动伴随着自发的或感官诱发的睡眠、梳洗、消费或其他此类持续行为的中断。 (5) 在整个 NE-LC 中的记录中，这些特征放电特性在地形上是均匀的。 (6)多个单位群体的神经元之间的阶段性鲁棒活动显着同步。 (7) 场电位在 NE-LC 中自发发生，并与同一电极的单位活动爆发同步。 (8) 在矛盾睡眠期间，场电位与单位活动分离，在几乎没有脉冲的情况下表现出最高的速率。这些结果与之前的观点基本一致，即 NE-LC 系统参与调节皮质和行为唤醒。根据目前的数据和以下报告中描述的数据（Aston-Jones, G., and F. E. Bloom (1981) J. Neurosci.1: 887–900），我们得出结论，这些神经元可能在一般唤醒框架内介导特定功能。简而言之，NE-LC 系统可能会全局偏置目标神经元的反应性，从而影响整体行为方向。
Spontaneous discharge of norepinephrine-containing locus coeruleus (NE- LC) neurons was examined during the sleep-walking cycle (S-WC) in behaving rats. Single unit and multiple unit extracellular recordings yielded a consistent set of characteristic discharge properties. (1) Tonic discharge co-varied with stages of the S-WC, being highest during waking, lower during slow wave sleep, and virtually absent during paradoxical sleep. (2) Discharge anticipated S-WC stages as well as phasic cortical activity, such as spindles, during slow wave sleep. (3) Discharge decreased within active waking during grooming and sweet water consumption. (4) Bursts of impulses accompanied spontaneous or sensory-evoked interruptions of sleep, grooming, consumption, or other such ongoing behavior. (5) These characteristic discharge properties were topographically homogeneous for recordings throughout the NE-LC. (6) Phasic robust activity was synchronized markedly among neurons in multiple unit populations. (7) Field potentials occurred spontaneously in the NE-LC and were synchronized with bursts of unit activity from the same electrodes. (8) Field potentials became dissociated from unit activity during paradoxical sleep, exhibiting their highest rates in the virtual absence of impulses. These results are generally consistent with previous proposals that the NE-LC system is involved in regulating cortical and behavioral arousal. On the basis of the present data and those described in the following report (Aston-Jones, G., and F. E. Bloom (1981) J. Neurosci.1: 887–900), we conclude that these neurons may mediate a specific function within the general arousal framework. In brief, the NE-LC system may globally bias the responsiveness of target neurons and thereby influence overall behavioral orientation.