The effect of degenerative morphological changes of the intervertebral disc on the lumbar spine biomechanics: a poroelastic finite element investigation
The effect of degenerative morphological changes of the intervertebral disc on the lumbar spine biomechanics: a poroelastic finite element investigation
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DOI：
10.1080/10255842.2010.493522
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发表时间：
2011-01-01
影响因子：
1.6
通讯作者：
Wilke, Hans-Joachim
中科院分区：
文献类型：
--
作者：
Galbusera, Fabio;Schmidt, Hendrik;Wilke, Hans-Joachim
腰椎间盘退变涉及脊柱解剖结构的改变。研究了以下变化的力学相关性：椎间盘高度、终板硬化、椎间盘含水量、通透性和减压。采用L4-L5脊柱节段的孔弹性非线性有限元模型。载荷为一天周期(500N压缩结合屈伸运动16h，然后200N压缩8h)。在非退变的情况下，该模型预测的昼夜轴向位移为1.32 mm，最大椎间盘内压为0.47兆帕。屈伸时的轴向位移、小关节力和活动范围随着椎间高度的降低而减小。随着初始含水率的降低，轴向位移、面力和滤失量都有所减小。终板硬化对计算结果没有显著影响。减压决定了椎间盘有效应力的增加，可能会导致失效。在任何模拟中都没有计算简并不稳定性。
Intervertebral disc degeneration involves changes in the spinal anatomical structures. The mechanical relevance of the following changes was investigated: disc height, endplate sclerosis, disc water content, permeability and depressurisation. A poroelastic nonlinear finite element model of the L4-L5 human spine segments was employed. Loads represented a daily cycle (500N compression combined with flexion-extension motion for 16 h followed by 200N compression for 8 h). In non-degenerative conditions, the model predicted a diurnal axial displacement of 1.32mm and a peak intradiscal pressure of 0.47 MPa. Axial displacement, facet force and range of motion in flexion-extension are decreased by decreasing disc height. By decreasing the initial water content, axial displacement, facet force and fluid loss were all reduced. Endplate sclerosis did not have a significant influence on the calculated results. Depressurisation determined an increase of the disc effective stress, possibly inducing failure. Degenerative instability was not calculated in any simulations.