Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: A diffusion tensor imaging study
Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: A diffusion tensor imaging study
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DOI：
10.1016/j.schres.2007.05.044
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发表时间：
2007-09-01
影响因子：
4.5
通讯作者：
Murai, Toshiya
中科院分区：
文献类型：
--
作者：
Fujiwara, Hironobu;Namiki, Chihiro;Murai, Toshiya
有证据表明，边缘系统网络完整性的破坏，特别是扣带回可能在精神分裂症的病理生理学中发挥作用。扣带束（CBs;后部和前部）是边缘系统中最突出的白色物质束，向扣带回提供输入和输出。在以前的扩散张量成像（DTI）的研究，异常的完整性已被证明在前CB部分，但不是后，精神分裂症。此外，CB完整性异常与精神分裂症的精神病理学之间的关系仍有待阐明。应用3 T磁共振成像仪获得的弥散张量成像（DTI）技术，检测了42例精神分裂症患者和24例对照组的前后脑束各向异性分数（FA）。此外，我们调查CB异常和精神分裂症的精神病理学之间的关系。在精神分裂症患者中，双侧FA减少在前部和后部CBs中被证明。然而，FA减少的模式是不同的前，后CBs之间：减少FA左加重在前CBs，而没有这种偏侧的异常被发现在后CBs。最后，在精神分裂症患者中，后部CBs的FA与阳性症状评分相关。这些研究结果表明，CB异常精神分裂症不仅限于前CB，但也包括后。后CB的病理可能是精神分裂症阳性症状的神经基础之一。(c)2007 Elsevier B. V.保留所有权利。
Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus may play a role in the pathophysiology of schizophrenia. The cingulum bundles (CBs; posterior and anterior) are the most prominent white matter tracts in the limbic system, furnishing both input and output to the cingulate gyrus. In previous diffusion tensor imaging (DTI) studies, abnormal integrity has been demonstrated in the anterior CB portion, but not the posterior, in schizophrenia. As well, the relationships between the abnormalities of CB integrity and the psychopathology of schizophrenia remain to be elucidated. Using DTI acquired on a 3 T MRI machine, we examined fractional anisotropy (FA) in the anterior and posterior CBs of 42 patients with schizophrenia and 24 group-matched controls. Moreover, we investigated the relationships between CB abnormalities and the psychopathology of schizophrenia. Bilaterally reduced FA was demonstrated in both anterior and posterior CBs in schizophrenia patients. However, the pattern of FA reduction was different between anterior and posterior CBs: the reduction in FA was leftaccentuated in anterior CBs, while no such lateralized abnormality was found in posterior ones. Finally, FA in posterior CBs correlated with positive symptom scores in patients with schizophrenia. These findings suggest that CB abnormalities in schizophrenia are not restricted to the anterior CB, but include the posterior as well. Pathology in the posterior CB would be one of the possible neural underpinnings of positive symptoms in schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.