Maternal smoking and causes of very preterm birth
Maternal smoking and causes of very preterm birth
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DOI：
10.1111/j.0001-6349.2005.00848.x
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发表时间：
2005-06-01
影响因子：
4.3
通讯作者：
Cnattingius, S
中科院分区：
文献类型：
--
作者：
Kyrklund-Blomberg, NB;Granath, F;Cnattingius, S
背景吸烟会增加早产的风险。本研究旨在阐明吸烟与早产的关系。在斯德哥尔摩1988-1992年对两个地区所有早产儿进行的病例对照研究中，从产前和分娩记录中提取了前瞻性收集的数据，包括吸烟、其他母亲特征、妊娠并发症和早产原因。例为活产单胎，胎龄≥ 10支/天）分别为1.4（95% CI 0.8-2.4）和2.9（95% CI 1.5-5.7）。与不吸烟者相比，中度和重度吸烟者的早产风险增加[OR分别为1.9（95% CI 1.0-3.6）和2.6（95% CI 1.1-1.6）]。这些风险在没有可识别的早产原因（“特发性早产”）的女性中基本保持不变。吸烟还与剂量依赖性增加早产风险有关，早产风险是由于早产、胎膜早破和晚期妊娠眼睑炎。吸烟与高血压引起的极早产风险之间无相关性。吸烟会增加早产（包括特发性早产）、早产胎膜早破和晚期妊娠眼睑炎引起的极早产的风险。
Background. Smoking increases the risk of preterm birth. The present study was made to elucidate the relation of smoking to causes of very preterm birth.Methods. In a case-control study on all very preterm births in two regions of Stockholm 1988-1992, prospectively collected data were extracted from antenatal and delivery records on smoking, other maternal characteristics, pregnancy complications, and causes of preterm birth. Cases were live single births with a gestational age of = 10 cigarettes per day) were 1.4 (95% CI 0.8-2.4) and 2.9 (95% CI 1.5-5.7), respectively. Compared with non-smokers, risk of preterm labor was increased among moderate and heavy smokers [ORs 1.9 (95% CI 1.0-3.6) and 2.6 (95% CI 1.1-1.6), respectively]. These risks remained essentially unchanged in women without an identifiable cause of preterm labor ('idiopathic preterm labor'). Smoking was also associated with dose-dependent increases in risks of preterm birth due to preterm premature rupture of membranes and late pregnancy bleedings. There was no association between smoking and risk of very preterm birth caused by hypertensive diseases.Conclusions. Smoking increases the risk of very preterm birth caused by preterm labor (including idiopathic preterm labor), preterm premature rupture of membranes, and late pregnancy bleedings.