Lymphangiogenesis and angiogenesis rescue murine ischemic hindlimb via transient receptor potential vanilloid 4
Lymphangiogenesis and angiogenesis rescue murine ischemic hindlimb via transient receptor potential vanilloid 4
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DOI：
10.1016/j.jphs.2021.04.009
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发表时间：
2021-05-24
影响因子：
3.5
通讯作者：
Kodama，Shohta
中科院分区：
文献类型：
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作者：
Yamada，Hideaki;Sakata，Naoaki;Kodama，Shohta
在本研究中，我们评估了瞬时受体电位香草素4(TRPV4)促进淋巴管/血管生成的调节作用，以改善后肢缺血动物模型，结果表明：(1)TRPV4激动剂通过诱导血管生成和淋巴管生成改善缺血后肢的血流量；(2)在缺血后肢淋巴管内皮细胞(LECs)上检测到TRPV4的过度表达；(3)低氧条件下促进钙通过TRPV4内流到LECs。通过激活TRPV4上调淋巴管和血管的表达被认为是治疗外周动脉疾病的一种很有前途的策略。
In this study, we assessed the regulation of transient receptor potential vanilloid 4 (TRPV4) promoting lymphangio/angiogenesis to improve the ischemic hindlimb animal model, and revealed that (1) a TRPV4 agonist improved the blood flow of ischemic hindlimbs by inducing both angiogenesis and lymphangiogenesis; (2) excessive TRPV4 expression was detected on lymphatic endothelial cells (LECs) in the ischemic hindlimb; and (3) hypoxic conditions promoted Ca2+influx into LECs via TRPV4. It is considered that the upregulation of both lymphatic and blood vessels by activating TRPV4 would be a promising therapeutic strategy for peripheral artery disease.