SUBARACHNOID DISTRIBUTION OF DRUGS AFTER LUMBAR INJECTION
SUBARACHNOID DISTRIBUTION OF DRUGS AFTER LUMBAR INJECTION
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DOI：
10.1056/nejm196212202672502
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发表时间：
1962-01-01
影响因子：
158.5
通讯作者：
FREIREICH, EJ
中科院分区：
文献类型：
--
作者：
RIESELBACH, RE;DICHIRO, G;FREIREICH, EJ
本文用放射自显影和造影术，以及人体三维外扫描、放射自显影和组织学观察，确定了注射到腰囊内的物质在蛛网膜下腔的分布。注入溶液的体积是获得广泛分布的重要因素。当注射估计的脑脊液体积的10%时，在基底池中达到显着的浓度。当大约25%的估计脑脊液被注射到猴子体内时，分布在整个大脑蛛网膜下腔和脑室系统。
The subarachnoid distribution of material injected into the lumbar sac was determined by autoradiography and contrast radiography in monkeys and by 3-dimensional external scanning, autoradiography and histologic observation in human patients. The volume of injected solution is an important factor in attaining widespread distribution. When 10% of estimated cerebrospinal-fluid volume was injected significant concentration was achieved in the basal cisterns. When approximately 25% of estimated cerebrospinal fluid was injected in monkeys, distribution was obtained throughout the cerebral sub-arachnoid space and ventricular system.