HETEROGENEITY OF TEMPO AND MODE OF MITOCHONDRIAL-DNA EVOLUTION AMONG MAMMALIAN ORDERS
HETEROGENEITY OF TEMPO AND MODE OF MITOCHONDRIAL-DNA EVOLUTION AMONG MAMMALIAN ORDERS
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DOI：
10.1266/jjg.64.243
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发表时间：
1989-08-01
期刊：
影响因子：
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通讯作者：
KISHINO, H
中科院分区：
文献类型：
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作者：
HASEGAWA, M;KISHINO, H
对人类、牛和小鼠的线粒体基因组完整DNA序列数据（以及大鼠的部分序列）进行的统计分析表明，牛的颠换率低于人类和鼠类，且人类的颠换率可能低于鼠类。然而，尚不清楚牛的转换率是否也较低。研究表明，人类线粒体DNA的L链含有的C含量明显高于牛和鼠类，而T和A含量则低于它们。这表明一种倾向于改变碱基组成的定向突变压力一直在人类谱系中起作用。
A statistical analysis of complete DNA sequence data of mitochondrial genomes from human, bovine, and mouse (and partial sequence of rat) indicates that the transversion rate is lower in bovine than in human and murids, and that it is probably lower in human than in murids. However, it is unknown whether the transition rate is also lower in bovine. It is shown that the L-strand of human mitochondrial DNA has significantly higher C content and lower T and A contents than those of bivine and murids. This suggests that a directional mutation pressure which tends to change base composition has been operating in the human lineage.