Benign paroxysmal torticollis: phenotype, natural history, and quality of life.

Benign paroxysmal torticollis: phenotype, natural history, and quality of life.
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DOI:
10.1038/s41390-020-01309-1
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发表时间:
2021-11
期刊:
影响因子:
3.6
通讯作者:
Gelfand AA
Gelfand AA
中科院分区:
医学3区
文献类型:
--
作者:
Greene KA;Lu V;Luciano MS;Qubty W;Irwin SL;Grimes B;Gelfand AA

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良性阵发性斜颈(BPT)在儿童早期以头部倾斜发作为特征,伴有呕吐、易怒和/或共济失调。BPT与偏头痛有关,但风险因素尚不清楚。对生活质量的影响也是未知的。患有持续或已确诊BPT的儿童的父母/照顾者参与了电话访谈(n=73)。那些正在进行BPT的人完成了婴儿蹒跚学步生活质量问卷(ITQOL)。访谈时儿童的平均年龄为2.9岁(范围为0.25-23岁)。52%(n=38)的BPT仍在进行中。19%(n=14)发展为偏头痛(中位年龄9.25岁,范围2.5-23),63%(n=46)发展为与偏头痛相关的另一种发作综合征。在BPT发作期间有某些偏头痛症状的患者中,发生偏头痛的比例高于没有的患者:畏音(58%比21%,p=0.02),畏光和畏音(55vs.23%,p=0.05),以及畏光、畏音和运动敏感性(60vs.22%,p=0.02)。ITQOL结果显示BPT对生活质量有显著影响。患有BPT的儿童可能会出现偏头痛或其他与偏头痛相关的发作性综合征。在BPT发作期间出现偏头痛特征可能会增加发生偏头痛的可能性。尽管BPT的特征是“良性的”,但它可以对儿童和家庭产生重大影响。
Benign paroxysmal torticollis (BPT) is characterized by attacks of head tilt associated with vomiting, irritability, and/or ataxia in early childhood. BPT is associated with migraine but risk factors are unknown. Impact on quality of life is also unknown. Parents/caregivers of children with ongoing or resolved BPT participated in telephone interviews (n = 73). Those with ongoing BPT completed the Infant Toddler Quality of Life questionnaire (ITQoL). Median age of children at the time of interview was 2.9 years (range 0.25–23). BPT was ongoing in 52% (n = 38). Nineteen percent (n = 14) developed migraine (median age 9.25 years, range 2.5–23) and 63% (n = 46) developed another episodic syndrome associated with migraine. Proportion of patients who developed migraine was higher among those with certain migrainous symptoms during BPT attacks vs. those without: phonophobia (58 vs. 21%, p = 0.02), photophobia and phonophobia (55 vs. 23%, p = 0.05), and photophobia, phonophobia, and motion sensitivity (60 vs. 22%, p = 0.02). ITQoL results showed significant impact of BPT on quality of life. Children with BPT may develop migraine or other episodic syndromes associated with migraine. Presence of migrainous features during BPT episodes may increase likelihood of developing migraine. Though characterized as “benign,” BPT can significantly impact children and families.
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