Connecting aging biology and inflammation in the omics era.
Connecting aging biology and inflammation in the omics era.
复制标题
将衰老生物学和组学时代的炎症联系起来。
DOI：
10.1172/jci158448
复制
发表时间：
2022-07-15
影响因子：
15.9
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Walker, Keenan A.;Basisty, Nathan;Wilson, David M., III;Ferrucci, Luigi
Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, termed inflammaging. Inflammaging has been implicated in the pathogenesis of many age-associated chronic diseases as well as loss of physical and cognitive function. The search for mechanisms that underlie inflammaging focused initially on the hallmarks of aging, but it is rapidly expanding in multiple directions. Here, we discuss the threads connecting cellular senescence and mitochondrial dysfunction to impaired mitophagy and DNA damage, which may act as a hub for inflammaging. We explore the emerging multi-omics efforts that aspire to define the complexity of inflammaging — and identify molecular signatures and novel targets for interventions aimed at counteracting excessive inflammation and its deleterious consequences while preserving the physiological immune response. Finally, we review the emerging evidence that inflammation is involved in brain aging and neurodegenerative diseases. Our goal is to broaden the research agenda for inflammaging with an eye on new therapeutic opportunities.
