Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior.
Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior.
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DOI：
10.1126/science.aac9698
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Deisseroth K
中科院分区：
文献类型：
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作者：
Ferenczi EA;Zalocusky KA;Liston C;Grosenick L;Warden MR;Amatya D;Katovich K;Mehta H;Patenaude B;Ramakrishnan C;Kalanithi P;Etkin A;Knutson B;Glover GH;Deisseroth K
奖励动机驱动适应性行为，而奖励感知和体验的损害（快感缺失）可能导致精神疾病，包括抑郁症和精神分裂症。我们试图检验这一假设，即内侧前额叶皮层（mPFC）控制特定的皮质下区域，支配享乐反应之间的相互作用。通过使用光遗传学功能磁共振成像来局部操纵但全局可视化大鼠的神经活动，我们发现多巴胺神经元刺激驱动纹状体活动，而局部增加的mPFC兴奋性降低了这种纹状体反应并抑制了多巴胺能刺激的行为驱动。这种慢性mPFC过度活动也稳定地抑制自然奖励动机行为，并诱导特定的新的全脑功能相互作用，预测个体的快感缺乏程度。这些研究结果描述了一种机制，其中mPFC调制奖励寻求行为的表达，通过调节特定的远距离皮层下区域之间的动态相互作用。
Motivation for reward drives adaptive behaviors, whereas impairment of reward perception and experience (anhedonia) can contribute to psychiatric diseases, including depression and schizophrenia. We sought to test the hypothesis that the medial prefrontal cortex (mPFC) controls interactions among specific subcortical regions that govern hedonic responses. By using optogenetic functional magnetic resonance imaging to locally manipulate but globally visualize neural activity in rats, we found that dopamine neuron stimulation drives striatal activity, whereas locally increased mPFC excitability reduces this striatal response and inhibits the behavioral drive for dopaminergic stimulation. This chronic mPFC overactivity also stably suppresses natural reward-motivated behaviors and induces specific new brainwide functional interactions, which predict the degree of anhedonia in individuals. These findings describe a mechanism by which mPFC modulates expression of reward-seeking behavior, by regulating the dynamical interactions between specific distant subcortical regions.