The effects of adjuvant chemotherapy on cognition in women with breast cancer - preliminary results of an observational longitudinal study
The effects of adjuvant chemotherapy on cognition in women with breast cancer - preliminary results of an observational longitudinal study
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DOI：
10.1016/j.breast.2004.10.004
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发表时间：
2005-04-01
期刊：
影响因子：
3.9
通讯作者：
Bloomfield, D
中科院分区：
文献类型：
--
作者：
Shilling, V;Jenkins, V;Bloomfield, D
一些研究报告说，与对照组相比，接受化疗的患者认知功能受损。我们正在进行一项纵向研究，在基线、6个月和18个月进行认知评估。对50名化疗患者和43名健康对照在基线和治疗后的数据进行了有计划的初步分析，发现在言语记忆和工作记忆的三项指标上存在显着的按时间分组的交互作用。化疗患者比对照组更容易表现出认知能力下降(OR 2.25)。患者更有可能有GHQ(12)分，表明可能的心理疾病，并在治疗后内分泌症状和疲劳显着增加，但无论是GHQ(12)还是生活质量变量都与认知表现无关。(C)2004爱思唯尔有限公司。保留所有权利。
Several studies have reported that chemotherapy-treated patients have impaired cognition function relative to control groups. We are conducting a longitudinal study with cognitive assessments at baseline, 6 and 18 months. A planned preliminary analysis of data from 50 chemotherapy patients and 43 healthy controls at baseline and post-treatment found a significant group by time interaction on three measures of verbal and working memory. Chemotherapy patients were more likely to show cognitive decline than controls (OR 2.25). Patients were significantly more likely to have GHQ(12) scores indicative of possible psychological morbidity and showed significant increases in endocrine symptoms and fatigue post-treatment however neither GHQ(12) nor quality-of-life variables were related to cognitive performance. (c) 2004 Elsevier Ltd. All rights reserved.