Gene expression profiles of human breast cancer progression
Gene expression profiles of human breast cancer progression
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DOI：
10.1073/pnas.0931261100
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发表时间：
2003-05-13
影响因子：
11.1
通讯作者：
Sgroi, DC
中科院分区：
文献类型：
--
作者：
Ma, XJ;Salunga, R;Sgroi, DC
尽管乳腺癌不同的病理阶段已被描述，但这些阶段之间的分子差异在很大程度上是未知的。在此，通过联合使用激光捕获显微切割技术和DNA微阵列，我们绘制了人类乳腺癌癌前、浸润前和浸润阶段的原位基因表达谱。我们的数据显示，在疾病进展的不同阶段，转录组水平存在广泛的相似性，并表明赋予浸润性生长潜力的基因表达改变在浸润前阶段就已存在。与肿瘤分期不同，不同的肿瘤分级与不同的基因表达特征相关。此外，一部分与高肿瘤分级相关的基因与从浸润前到浸润性生长的转变存在定量相关性。
Although distinct pathological stages of breast cancer have been described, the molecular differences among these stages are largely unknown. Here, through the combined use of laser capture microdissection and DNA microarrays, we have generated in situ gene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer. Our data reveal extensive similarities at the transcriptome level among the distinct stages of progression and suggest that gene expression alterations conferring the potential for invasive growth are already present in the preinvasive stages. In contrast to tumor stage, different tumor grades are associated with distinct gene expression signatures. Furthermore, a subset of genes associated with high tumor grade is quantitatively correlated with the transition from preinvasive to invasive growth.