CSF D-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls
CSF D-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls
复制标题
DOI：
10.1016/j.neurobiolaging.2016.03.017
复制
发表时间：
2016-06-01
影响因子：
4.2
通讯作者：
Verbeek, Marcel M.
中科院分区：
文献类型：
--
作者：
Biemans, Elisanne A. L. M.;Verhoeven-Duif, Nanda M.;Verbeek, Marcel M.
最近报道，脑脊液（CSF）中D-丝氨酸水平作为阿尔茨海默病（AD）的潜在新生物标志物，显示AD患者和健康对照之间的完美区别。在这项研究中，我们的目的是证实这些结果，并将这些先前的发现扩展到路易体痴呆和额颞叶痴呆。采用超高效液相色谱-串联质谱法测定了29例AD患者、8例路易体痴呆患者、14例额颞叶痴呆患者和28例非痴呆对照者脑脊液中D-丝氨酸水平。与以前的研究结果相反，在我们的研究中，与对照组相比，AD患者的CSF D-丝氨酸水平仅略有增加。AD患者的CSF D-丝氨酸与其他痴呆患者没有差异，也与最低精神状态检查评分无关。由于D-丝氨酸水平的大量重叠，我们得出结论，CSF D-丝氨酸既不是AD的合适生物标志物，也不是认知功能下降的合适生物标志物。(C)2016 Elsevier Inc. All rights reserved.
Cerebrospinal fluid (CSF) levels of D-serine were recently reported as a potential new biomarker for Alzheimer's disease (AD), showing a perfect distinction between AD patients and healthy controls. In this study, we aimed to confirm these results and extend these previous findings to dementia with Lewy bodies and frontotemporal dementia. D-Serine levels in CSF of 29 AD patients, 8 dementia with Lewy bodies patients, 14 frontotemporal dementia patients, and 28 nondemented controls were measured using ultra-high-performance liquid chromatography-tandem mass spectrometry. In contrast to previous findings, in our study CSF D-serine levels were only slightly increased in AD patients compared with controls. CSF D-serine in AD did not differ from other dementias and was also not correlated to minimental state examination-scores. Owing to the large overlap of D-serine levels, we conclude that CSF D-serine is neither a suitable biomarker for AD nor for cognitive decline. (C) 2016 Elsevier Inc. All rights reserved.