The combination of mifepristone and misoprostol for the termination of pregnancy
The combination of mifepristone and misoprostol for the termination of pregnancy
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DOI：
10.1016/j.ijgo.2011.07.013
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发表时间：
2011-10-01
影响因子：
3.8
通讯作者：
Faundes, Anibal
中科院分区：
文献类型：
--
作者：
Faundes, Anibal
服用200毫克米非司酮和25-800毫克米索前列醇(视胎龄而定)的组合已被证明在整个妊娠期间对终止妊娠有效。米索前列醇的剂量应随着胎龄的增加而减少。米非司酮没有用于活体胎儿引产的适应证，因为没有数据证实它没有可能对胎儿产生有害影响。介绍了药物流产的疗程和先决条件，不同胎龄的米非司酮和米索前列醇的推荐方案，以及副作用、并发症的处理和流产后的护理。米非司酮-米索前列醇联合方案在胎儿死亡病例引产中的使用也被描述。(C)2011年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
The combination of 200 mg of mifepristone followed by 25 mu g to 800 mu g (depending on gestational age) of misoprostol has been shown to be effective for the termination of pregnancy throughout gestation. The dose of misoprostol should be reduced as gestational age increases. Mifepristone is not indicated for induction of labor with a live fetus because there are no data to confirm that it does not have a possible deleterious fetal effect. The course of treatment and prerequisites for medical abortion and recommended mifepristone and misoprostol regimens for different gestational ages are described, along with the side effects, management of complications, and postabortion care. The use of the mifepristone-misoprostol combination regimen for induction of labor in cases of fetal death is also described. (C) 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.