Effect of ligature placement and dental plaque on periodontal tissue breakdown in the dog.
Effect of ligature placement and dental plaque on periodontal tissue breakdown in the dog.
复制标题
结扎位置和牙菌斑对狗牙周组织破坏的影响。
DOI：
10.1902/jop.1978.49.7.343
复制
发表时间：
1978
影响因子：
4.3
通讯作者：
I. Ericsson
中科院分区：
文献类型：
--
作者：
J. Lindhe;I. Ericsson
Saxe等，1 Svanberg等，2和Lindhe et a l . 3，4已经揭示，在存在菌斑感染的情况下，在大多数情况下，狗的牙龈炎最终发展成进行性牙周炎。在研究中提到牙龈炎转化为进行性牙周炎需要1至3年的实验。为了加速狗牙龈炎向牙周炎的转化，从而便于分析与这种转化相关的组织改变，已经利用了不同的模型系统。这些模型涉及的程序包括：（1）粘骨膜瓣的提升，（2）牙槽骨嵴皮质层的消除，以及（3）在牙菌斑感染的牙列中在牙颈部周围应用结扎线。这类实验也在老鼠和猴子身上进行过。10，11 Rovin等人的论文。10建立了迄今为止报道的所有“结扎应用”研究的基线。他们研究了细菌对无菌大鼠和常规大鼠牙周病发生的影响。为了产生“牙龈刺激，在下颌第一磨牙的颈部边缘放置丝线结扎”。在传统的，但不是在无菌大鼠，结扎放置在几个星期内导致一个显着的炎症的支持组织。这意味着，结扎线放置的疾病诱导潜力似乎是微生物和结扎线共同存在的结果。
EXPERIMENTS REPORTED by Saxe et al. , 1 Svanberg et al., 2 and Lindhe et a l . 3 , 4 have revealed that in the presence of a plaque infection, gingivitis in dogs in most instances eventually develops into progressive periodontitis. In the studies referred to the conversion of gingivitis into progressive periodontitis required between 1 and 3 years of experiment. In order to accelerate the conversion of gingivitis into periodontitis in dogs and hence to facilitate analyses of tissue alterations related to this transition, different model systems have been utilized. 5 9 These models have involved procedures such as: (1) the raising of mucoperiosteal flaps, (2) the elimination of the cortical layer of the alveolar bone crest, and (3) the application of ligatures around the neck of teeth in plaque infected dentitions. Experiments of this kind also have been carried out in rats and in monkeys. 1 0 , 1 1 A paper by Rovin et a l . 1 0 establishes the baseline for all the "ligature application" studies hitherto reported. They studied the influence of bacteria on the initiation of periodontal disease in germfree and conventional rats. In order to produce "gingival irritation, silk ligatures were placed at the cervical margins of the mandibular first molars". In the conventional, but not in the germfree rats, ligature placement within a few weeks resulted in a marked inflammation of the supporting tissues. This means, that the disease inducing potential of ligature placement, seemed to be the result of the combined presence of microorganisms and the ligature.