Inhibition of microtubule polymerization by synthetic estrogens: formation of a ribbon structure.
Inhibition of microtubule polymerization by synthetic estrogens: formation of a ribbon structure.
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合成雌激素抑制微管聚合：带状结构的形成。
DOI：
10.1093/oxfordjournals.jbchem.a121988
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发表时间：
1987
影响因子：
2.7
通讯作者：
A. Hirata
中科院分区：
文献类型：
--
作者：
Y. Sato;T. Murai;T. Oda;H. Saitŏ;M. Kodama;A. Hirata
二烯雌酚，meso-hexestrol和dl-hexestrol，合成的非甾体雌激素，被证明是微管组装的抑制剂，在体外使用微管蛋白分离自猪脑。合成雌激素作为微管组装抑制剂的活性顺序为：二烯雌酚大于己烯雌酚大于内消旋己雌酚大于dl-己雌酚大于异二烯雌酚。双烯雌酚作为抑制剂的活性与（+）-灰黄霉素的活性具有相同的数量级，如通过浊度测量所确定的。电子显微镜观察显示，扭曲的带状结构形成的微管蛋白在一些合成雌激素（双烯雌酚，meso-hexestrol，和dl-hexestrol）的存在下。
Dienestrol, meso-hexestrol, and dl-hexestrol, synthetic nonsteroidal estrogens, were shown to be inhibitors of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The order of activity of the synthetic estrogens as inhibitors of microtubule assembly is: dienestrol greater than diethylstilbestrol greater than meso-hexestrol greater than dl-hexestrol greater than isodienestrol. The activity of dienestrol as an inhibitor was of the same order as that of (+)-griseofulvin, as determined by turbidity measurement. Electron microscopic observation revealed that twisted ribbon structures are formed from microtubule proteins in the presence of some synthetic estrogens (dienestrol, meso-hexestrol, and dl-hexestrol).