Neuropsychiatric symptoms in workers occupationally exposed to jet fuel — a combined epidemiological and casuistic study
Neuropsychiatric symptoms in workers occupationally exposed to jet fuel — a combined epidemiological and casuistic study
复制标题
职业接触喷气燃料的工人的神经精神症状——一项流行病学和毒理学研究相结合
DOI：
10.1111/j.1600-0447.1983.tb00942.x
复制
发表时间：
1983
影响因子：
6.7
通讯作者：
P. Mindus
中科院分区：
文献类型：
--
作者：
G. Struwe;B. K. and;P. Mindus
一些飞机和航空业的工作人员暴露于喷气燃料，脂肪烃（石油80%）和一些有机溶剂（芳烃20%）的混合物。为了评估这种长期职业暴露的可能神经精神后遗症，我们在一家喷气发动机厂检查了30名工人，暴露于约250 mg/m3的水平，持续4-32年。将他们与两个对照组（2 × 30）的匹配非暴露工人进行比较。首先通过标准化访谈和检查工厂医生保存的病历来评估病史。暴露组受试者在就业后因抑郁、焦虑等情绪障碍而就医的次数明显多于对照组（P < 0.005）。当精神科医生对提示脑损伤的精神症状进行评分时，接触组得分高于对照组（P < 0.001）。然后选择表现出最多症状的14名受试者进行彻底的神经精神临床调查，包括心理社会调查、心理测试、人格评估和神经/神经生理学检查。7例被判定患有轻度器质性脑综合征（即“器质性神经衰弱”），其中1例受试者为重度病例。多年来，这些受试者都经历了缓慢但稳定的性格变化-从没有神经质特征的普通力量开始，逐渐走向疲劳，焦虑和植物性高反应的虚弱状态。除职业性暴露于喷气燃料外，无法确定造成这种变化的其他原因。得出的结论是，人格变化和情感功能障碍是这种长期暴露于石油产品的最主要影响。
Some aircraft personell and airline industry workers are exposed to jet fuel, a mixture of aliphatic hydrocarbons (petroleum 80%) and some organic solvents (aromatic hydrocarbons 20%). In order to evaluate the possible neuropsychiatric sequale of such long‐term occupational exposure, we examined 30 workers exposed at about 250 mg/m3 for 4—32 years at a jet motor factory. They were compared with two control groups (2 × 30) of matched non‐exposed workers. The medical history was first assessed by standardized interviews and examination of medical records kept by the factory physician. The exposed subjects had, after their employment, much more often saught medical advice because of emotional dysfunctions, such as depression and anxiety, than had the control groups (P < 0.005). When the prevalent mental symptoms, indicative of brain lesion, later were rated by psychiatrists, the exposed workers scored higher than did the controls (P < 0.001). 14 subjects showing most symptoms were then selected for a thorough neuropsychiatric clinical investigation comprising psychosocial inquiries, psychological testing, personality assessment and neurological/neurophysiological examinations. Seven were judged to suffer from mild organic brain syndrome (i.e. “organic neurasthenia”) of which one subject was a severe case. The subjects had all undergone a slow but steady personality change over the years — starting from an ordinary strength without neurotic traits and moving towards an asthenic state with fatigue, anxiety and vegetative hyperreactivity. No other cause for this change could be identified as an alternative to the occupational exposure to jet fuel. It is concluded that personality changes and emotional dysfunctions are the foremost effects of such long‐term exposure to petroleum products.