Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity
Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity
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Tabernaemontana corymbosa 中的单萜吲哚 N-氧化物生物碱及其抗菌活性
DOI：
10.1016/j.fitote.2022.105178
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发表时间：
2022-03-16
期刊：
影响因子：
3.4
通讯作者：
Yu, Hao-Fei
中科院分区：
文献类型：
--
作者：
Fan, Kun;Ding, Cai-Feng;Yu, Hao-Fei
伞房花蒙塔纳是一种传统的民间药物。本研究从木姜子的茎皮中分离得到6个单萜吲哚N-氧化物生物碱及其母体生物碱。包括7个新生物碱（1-7）和5个已知生物碱（8-12）。通过光谱、量子化学计算和DP 4+概率分析，确定了它们的结构和绝对构型。结果表明，生物碱4、8、12对金黄色葡萄球菌有明显的抗菌活性，MIC值为6.25 μ g/mL;生物碱11、12对枯草芽孢杆菌有一定的抗菌活性，MIC值为25 μ g/mL。
Tabernaemontana corymbosa is a traditional folk medicine. In our research, six monoterpene indole N-oxide alkaloids and their parent alkaloids were obtained from the stem bark of T. corymbosa, including seven new alkaloids (1-7) and five known alkaloids (8-12). Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, and DP4+ probability analyses. The antimicrobial activity of the obtained compounds was evaluated, among which alkaloids 4, 8, 12 showed significant antimicrobial activity against Staphylococcus aureus with an MIC value of 6.25 mu g/mL, while alkaloids 11, 12 showed moderate antimicrobial activity against Bacillus subtilis with an MIC value of 25 mu g/mL.