Monochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera
Monochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera
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DOI：
10.1016/j.phytochem.2016.10.001
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发表时间：
2016-12-01
期刊：
影响因子：
3.8
通讯作者：
Stadler, Marc
中科院分区：
文献类型：
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作者：
Chepkirui, Clara;Richter, Christian;Stadler, Marc
八个以前未描述的化合物被分离出来，其特征在于从真菌Favolaschia calocera的培养物的上清液和菌丝体的起源于肯尼亚的卡卡梅加赤道雨林。它们是：9-氧代嗜球果伞素A、G、K和I以及四种单氯化钙角蛋白A、B、C和D。calocerins扩展了我们从天然来源获得的卤代化合物的知识。还鉴定了另外四种已知化合物：嗜球果伞素G、favolon、蝶呤酸和2，3-二氢-1-苯并氧杂环庚烯衍生物。四种氧代嗜球果伞素具有显著的抗真菌和细胞毒活性，而四种钙角蛋白仅具有细胞毒活性。(C)2016爱思唯尔有限公司版权所有。
Eight previously undescribed compounds were isolated and characterised from the supernatant and mycelium of a culture of the basidiomycete Favolaschia calocera originating from Kakamega equatorial rainforest in Kenya. These were: 9- oxostrobilurins A, G, K and I and the four monochlorinated calocerins A, B, C and D. The calocerins extend our knowledge of halogenated compounds obtained from natural sources. Four further known compounds were also identified: strobilurin G, favolon, pterulinic acid and 2,3 -dihydro-l-benzoxepin derivative. The four oxostrobilurins exhibited prominent antifungal and cytotoxic activities while the four calocerins only showed cytotoxic activity. (C) 2016 Elsevier Ltd. All rights reserved.