Improved electrode material for deep brain stimulation.
Improved electrode material for deep brain stimulation.
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改进的用于深部脑刺激的电极材料。
DOI：
10.1109/embc.2016.7591067
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Weiland,JD
中科院分区：
文献类型：
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作者：
Petrossians,A;Whalen,JJ;Weiland,JD
脑深部电刺激（DBS）装置已被植入用于治疗基础性震颤、帕金森病和肌张力障碍。这些装置使用与组织接触的电极将电脉冲传递到靶细胞，以引起特定的治疗反应。一般来说，神经调节行业一直在朝着更小、侵入性更小的电极发展。然而，目前的电极材料不支持小尺寸而不严重限制刺激输出。因此，改进的电极材料将有益于当前和未来的DBS系统。在这项研究中，使用具有成本效益和材料效率的工艺对5根DBS电极导线进行了改良，以应用超低阻抗铂铱合金涂层。一根DBS电极导线用于插入测试，四根DBS电极导线长期脉冲12周。铂铱合金显著改善了DBS电极的电性能，并且对于插入大脑和12周的慢性脉冲来说是稳健的。
Deep brain stimulation (DBS) devices have been implanted for treatment of basic tremor, Parkinson's disease and dystonia. These devices use electrodes in contact with tissue to deliver electrical pulses to targeted cells, to elicit specific therapeutic responses. In general, the neuromodulation industry has been evolving towards smaller, less invasive electrodes. However, current electrode materials do not support small sizes without severely restricting the stimulus output. Hence, an improved electrode material will benefit present and future DBS systems. In this study, five DBS leads were modified using a cost-effective and materials-efficient process for applying an ultra-low impedance platinum-iridium alloy coating. One DBS lead was used for insertion test and four DBS leads were chronically pulsed for 12 weeks. The platinum-iridium alloy significantly improved the electrical properties of the DBS electrodes and was robust to insertion into brain and to 12 weeks of chronic pulsing.