Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme.
Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme.
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DOI：
10.1016/j.tem.2017.02.004
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Pissios P
中科院分区：
文献类型：
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作者：
Pissios P
烟酰胺N-甲基转移酶（NNMT）最初被鉴定为负责烟酰胺（NAM）甲基化的酶，NAM是维生素B3的一种形式。甲基化NAM（MNAM）最终从体内排出。最近的证据已经将NNMT的作用扩展到清除过量维生素B3之外。NNMT通过消耗甲基供体和产生活性代谢物，参与调节脂肪组织和肝脏等组织以及癌细胞中的多种代谢途径。本文综述了NNMT在生理和疾病中的功能，并强调了潜在的新途径的治疗干预的最新研究结果。最后，在我们的知识，这种酶系统和未来的调查领域的关键差距进行了讨论。
Nicotinamide N-methyltransferase (NNMT) was originally identified as the enzyme responsible for the methylation of nicotinamide (NAM), one of the forms of vitamin B3. Methylated NAM (MNAM) is eventually excreted from the body. Recent evidence has expanded the role of NNMT beyond clearance of excess vitamin B3. NNMT has been implicated in the regulation of multiple metabolic pathways in tissues such as the adipose tissue and liver, as well as cancer cells, through consumption of methyl donors and generation of active metabolites. This review examines recent findings regarding the function of NNMT in physiology and disease and highlights potential new avenues for therapeutic intervention. Finally, key gaps in our knowledge for this enzymatic system and future areas of investigation are discussed.