PERIODIC TRANSCRIPTION OF YEAST HISTONE GENES
PERIODIC TRANSCRIPTION OF YEAST HISTONE GENES
复制标题
DOI：
10.1016/0092-8674(82)90036-8
复制
发表时间：
1982-01-01
期刊：
影响因子：
64.5
通讯作者：
OSLEY, MA
中科院分区：
文献类型：
--
作者：
HEREFORD, L;BROMLEY, S;OSLEY, MA
Periodic transcription of yeast histone genes was demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, both activation and termination of transcription are determined by temporally separable (cell cycle) events. Activation of histone mRNA synthesis occurs late in G1, at a point prior to initiation of DNA replication. Cessation of histone mRNA synthesis depends on the entry of cells into S. A simple model for the control of histone gene transcription is suggested, in which changes in chromatin that must precede the initiation of DNA replication also bring about activation of histone mRNA synthesis. Cessation of synthesis would occur once this region had been replicated and the chromatin restored to its prereplicative state.
