Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
复制标题
DOI：
10.1111/cen.12383
复制
发表时间：
2014-08-01
影响因子：
3.2
通讯作者：
Martinez, Jose A.
中科院分区：
文献类型：
--
作者：
de la Iglesia, Rocio;Lopez-Legarrea, Patricia;Martinez, Jose A.
目的鸢尾素是新近发现的一种在能量代谢中起重要作用的肌细胞因子。本研究的目的是评估这种激素和代谢综合征（MetS）的患者的血脂之间的关系，以下hypocaloric diet.Design 93高加索成年人（52名男性/41名女性）诊断与MetS遵循8周长的能量限制计划（-30%的能量需求）。结果研究结束时，随着体重下降（-6.9%），血浆鸢尾素水平显著下降（-72.0 +/-100.9ng/ml，P < 0.001）。鸢尾素的消耗与一些致动脉粥样硬化相关变量的变化显着相关：总胆固醇（B = 0.106，P = 0.018），总胆固醇/高密度脂蛋白胆固醇比值（B = 0.002，P = 0.036），低密度脂蛋白胆固醇（B = 0.085，P = 0.037）和载脂蛋白B（B = 0.052，P = 0.002），结论：血浆鸢尾素水平的降低与重要的脂质代谢生物标志物的耗竭之间存在相关性，接受能量限制计划的代谢综合征患者。
Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet.Design Ninety-three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8-week-long energy-restricted programme (-30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention.Results Global plasma irisin levels were significantly reduced at the end of the study (-72.0 +/- 100.9 ng/ml, P < 0.001) accompanying the weight loss (-6.9%). The depletion of irisin significantly correlated with changes in some atherogenic-related variables: total cholesterol (B = 0.106, P = 0.018), total cholesterol/high-density lipoprotein cholesterol ratio (B = 0.002, P = 0.036), low-density lipoprotein cholesterol (B = 0.085, P = 0.037) and apolipoprotein B (B = 0.052, P = 0.002), independently of changes in body weight.Conclusions An association between the reduction in plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy-restricted programme.