Isoforms of vitamin E differentially regulate inflammation.
Isoforms of vitamin E differentially regulate inflammation.
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DOI：
10.2174/1871530311006040348
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
McCary CA
中科院分区：
文献类型：
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作者：
Cook-Mills JM;McCary CA
维生素 E 对疾病的调节作用已在人类、动物模型和细胞系统中得到广泛研究。这些研究大多数集中在维生素 E 的 α-生育酚亚型。这些报告表明维生素 E 的 α-生育酚亚型的抗炎功能的结果相互矛盾，特别是在哮喘和动脉粥样硬化的临床研究方面。这些看似不同的临床结果与最近报道的维生素 E 亚型的未被认识的特性是一致的。最近，据报道，纯化的天然形式的维生素 E 的生理水平在炎症过程中具有相反的调节功能。维生素 E 同工型生理水平的这些相反的调节功能影响了之前对维生素 E 研究的解释。此外，最近的其他研究还表明，使用具有相反免疫调节功能的维生素 E 同工型的生理水平时，维生素 E 同工型对炎症的影响只能部分可逆。因此，这进一步影响了对先前维生素 E 研究的解释，其中在研究开始之前存在炎症和大量维生素 E 亚型。总之，本综述将讨论维生素 E 对炎症的调节，包括对文献中有关维生素 E 亚型的先前研究的替代解释。
Vitamin E regulation of disease has been extensively studied in humans, animal models and cell systems. Most of these studies focus on the α-tocopherol isoform of vitamin E. These reports indicate contradictory outcomes for anti-inflammatory functions of the α-tocopherol isoform of vitamin E, especially with regards to clinical studies of asthma and atherosclerosis. These seemingly disparate clinical results are consistent with recently reported unrecognized properties of isoforms of vitamin E. Recently, it has been reported that physiological levels of purified natural forms of vitamin E have opposing regulatory functions during inflammation. These opposing regulatory functions by physiological levels of vitamin E isoforms impact interpretations of previous studies on vitamin E. Moreover, additional recent studies also indicate that the effects of vitamin E isoforms on inflammation are only partially reversible using physiological levels of a vitamin E isoform with opposing immunoregulatory function. Thus, this further influences interpretations of previous studies with vitamin E in which there was inflammation and substantial vitamin E isoforms present before the initiation of the study. In summary, this review will discuss regulation of inflammation by vitamin E, including alternative interpretations of previous studies in the literature with regards to vitamin E isoforms.