Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis
Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis
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脑室内干扰素治疗亚急性硬化性全脑炎
DOI：
10.1177/088307388900400103
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发表时间：
1989
影响因子：
1.9
通讯作者：
P. Dyken
中科院分区：
文献类型：
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作者：
I. Steiner;I. Wirguin;A. Morag;O. Abramsky;P. Dyken
用α-干扰素治疗3例亚急性硬化性全脑炎（SSPE）患儿。在13至24个月期间，通过Ommaya储药器向脑室系统给药，剂量递增至1.0 X 106 IU，每周两次。两名儿童的轻度临床改善和第三名儿童的稳定病程与所有患者脑电图记录的改善和两名患者脑脊液中抗麻疹抗体的降低相关。由于患者数量少，我们不能确定这一过程是否是SSPE的自然史，或者是否是由治疗引起的，但脑室内干扰素治疗似乎可以改变SSPE的过程。（J Child Neurol 1989;4：20-23）。
Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 X 106 IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE. ( J Child Neurol 1989;4:20-23).
Ryoko Koike，：“脂肪酸延长系统在肾上腺脑白质营养不良中的生理意义”J. Neurol。
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