Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits - Comparison with lovastatin
Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits - Comparison with lovastatin
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DOI：
10.1161/01.cir.96.4.1282
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发表时间：
1997-08-19
期刊：
影响因子：
37.8
通讯作者：
Frolich, JC
中科院分区：
文献类型：
--
作者：
Boger, RH;BodeBoger, SM;Frolich, JC
背景我们研究了L-精氨酸是否会引起既存动脉粥样硬化病变和逆转内皮功能障碍的高胆固醇血症的兔子，是否可以获得类似的效果，通过降胆固醇治疗与洛伐他汀，以及其机制导致这些effects.Methods和Results兔子喂1%的胆固醇4周和0.5%的胆固醇为额外的12周。在第5周至第16周期间，对两组胆固醇喂养的家兔进行L-精氨酸（2.0%饮用水）或洛伐他汀（10 mg/d）治疗。全身一氧化氮（NO）的形成是以每周为间隔的硝酸盐和cGMP的尿排泄率来评估的。胆固醇饮食逐渐减少尿硝酸盐排泄至基线的40%左右（P
Background We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects.Methods and Results Rabbits were fed 1% cholesterol for 4 weeks and 0.5% cholesterol for an additional 12 weeks. Two groups of cholesterol-fed rabbits were treated with L-arginine (2.0% in drinking water) or lovastatin (10 mg/d) during weeks 5 through 16. Systemic nitric oxide (NO) formation was assessed as the urinary excretion rates of nitrate and cGMP in weekly intervals. Cholesterol feeding progressively reduced urinary nitrate excretion to approximate to 40% of baseline (P