Role of cellular prion protein on LTP expression in aged mice
Role of cellular prion protein on LTP expression in aged mice
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DOI：
10.1016/j.brainres.2006.04.056
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发表时间：
2006-06-30
期刊：
影响因子：
2.9
通讯作者：
Ramirez, Oscar A.
中科院分区：
文献类型：
--
作者：
Maglio, Laura E.;Martins, Vilma R.;Ramirez, Oscar A.
近年来，细胞朊病毒蛋白（PrPc）被认为与一些生理功能有关。在之前的一篇论文中，我们已经证明缺乏这种蛋白质的成年小鼠海马突触传递增加。在本研究中，我们研究了衰老对缺乏PrPc蛋白（PrPc）的9月龄小鼠海马长期增强（LTP）的产生和维持的影响。我们观察到9月龄Pmp（0/0）小鼠诱导LTP的阈值较同龄野生型小鼠低。在Pmp0/0小鼠海马切片中，齿状回LTP的维持更为持久。老龄Prnp（0/0）动物海马NMDA谷氨酸受体NR2A和NR2B亚基mRNA表达较野生型增加。我们建议增加海马。Prnp0/0小鼠的谷氨酸传递与齿状LTP的可塑性和持久性增强有关。(c) 2006 Elsevier B.V.版权所有
Cellular prion protein (PrPc) has been associated with some physiological functions in the last few years. in a previous paper, we have demonstrated an increased hippocampal synaptic transmission in adult mice lacking this protein. In the present study, we investigate the impact of aging on the generation and maintenance of hippocampal long-term Potentiation (LTP) in 9-month-old mice devoid of PrPc protein (PrPc). We observed a lower threshold for inducing LTP in 9-month-old Pmp(0/0) mice compared to wild-type ones at the same age. The maintenance of dentate gyrus LTP was more persistent in hippocampal slices from Pmp0/0 mice. Furthermore, the expression of mRNA for NR2A and NR2B subunits of the NMDA glutamatergic receptor in hippocampus of aged Prnp(0/0) animals showed an increase compared to the wild type. We propose that increased hippocampal. glutamatergic transmission in Prnp0/0 mice is related to the enhanced plasticity and persistence of the dentate LTP. (c) 2006 Elsevier B.V. All rights reserved.