IFPA 2004 Award In Placentology Lecture - How to make a placenta: Mechanisms of trophoblast cell differentiation in mice - A review
IFPA 2004 Award In Placentology Lecture - How to make a placenta: Mechanisms of trophoblast cell differentiation in mice - A review
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DOI：
10.1016/j.placenta.2005.01.015
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发表时间：
2005-04-01
期刊：
影响因子：
3.8
通讯作者：
Cross, JC
中科院分区：
文献类型：
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作者：
Cross, JC
胎盘这个词来源于拉丁语，意思是“扁平的蛋糕”。尽管胎盘的名字很谦虚，但它是一个令人惊叹的器官，它既是母亲向胎儿选择性输送营养的接口，也是重新指导母亲代谢，内分泌，心血管和免疫功能，以促进胎儿的生存和生长。这两种功能由不同的特化滋养层细胞亚型实现，我的实验室一直在研究它们的形成和功能在胎盘发育过程中是如何调节的。通过培养细胞和组织的分子研究，小鼠的遗传研究，以及对人类，啮齿动物和农场动物胎盘的比较分析，现在可以描述控制所有主要滋养层细胞亚型和胎盘结构发育的分子途径。这项工作揭示了细胞间相互作用、环境因素和控制正常发育的分子网络的复杂性。(c)2005年由IFPA和Elsevier Ltd.出版
The word placenta is derived from the Latin term meaning 'flat cake'. Despite the rather humble name, the placenta is an amazing organ that forms both the interface for selective delivery of nutrients from the mother to the fetus and also re-directs maternal metabolic, endocrine, cardiovascular and immune functions to promote fetal survival and growth. These two functions are fulfilled by different specialized trophoblast cell subtypes, and my laboratory has been studying how their formation and functions are regulated during placental development. Through molecular studies in cultured cells and tissues, genetic studies in mice, and comparative analysis of placentas from humans, rodents and farm animals, it is now possible to describe molecular pathways that control the development of all major trophoblast cell subtypes and structures of the placenta. The work has revealed an intricate complexity of cell-cell interactions, environmental factors, and molecular networks that control normal development. (c) 2005 Published by IFPA and Elsevier Ltd.