A global health problem caused by arsenic from natural sources
A global health problem caused by arsenic from natural sources
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DOI：
10.1016/s0045-6535(03)00470-3
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发表时间：
2003-09-01
期刊：
影响因子：
8.8
通讯作者：
Shraim, A
中科院分区：
文献类型：
--
作者：
Ng, JC;Wang, JP;Shraim, A
砷对人类和动物都是致癌物质。砷与皮肤癌、肺癌和膀胱癌有关。慢性砷中毒的临床表现包括色素沉着过度和色素沉着不足、角化病、高血压、心血管疾病和糖尿病等非癌症终点。流行病学证据表明，饮用水中砷浓度超过50 μg l(-1) 不具有公共卫生保护作用。目前世界卫生组织推荐的饮用水中砷含量指导值为10μg l(-1)，而许多发展中国家的砷含量仍为50μg 1(-1)。据估计，有数千万人。面临暴露于污染水和天然含砷煤中砷含量超标的风险。本文还讨论了全球健康影响和可能的干预策略。 (C) 2003 Elsevier Ltd. 保留所有权利。
Arsenic is a carcinogen to both humans and animals. Arsenicals have been associated with cancers of the skin, lung, and bladder. Clinical manifestations of chronic arsenic poisoning include non-cancer end point of hyper- and hypo-pigmentation, keratosis, hypertension, cardiovascular diseases and diabetes. Epidemiological evidence indicates that arsenic concentration exceeding 50 mug l(-1) in the drinking water is not public health protective. The current WHO recommended guideline value for arsenic in drinking water is 10 mug l(-1), whereas many developing countries are still having a value of 50 mug 1(-1). It has been estimated that tens of millions of people are. at risk exposing to excessive levels of arsenic from both contaminated water and arsenic-bearing coal from natural sources. The global health implication and possible intervention strategies were also discussed in this review article. (C) 2003 Elsevier Ltd. All rights reserved.