Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.
Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.
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二烯丙基二硫化物通过上调 miR-34a 抑制人乳腺癌中 SRC/Ras/ERK 信号介导的增殖和转移
DOI：
10.1371/journal.pone.0112720
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Xiao X;Chen B;Liu X;Liu P;Zheng G;Ye F;Tang H;Xie X
二烯丙基二硫（DADS）是大蒜油的主要挥发性成分之一。DADS具有多种生物学特性，包括抗癌、抗血管生成和抗氧化作用。然而，DADS在人乳腺癌中的抗癌机制尚未阐明，特别是在体内。在这项研究中，我们证明了miR-34 a在DADS处理的MDA-MB-231细胞中的表达上调。miR-34 a不仅抑制乳腺癌生长，而且在体外和体内增强DADS的抗肿瘤作用。此外，Src被鉴定为miR-34 a的靶点，miR-34 a抑制SRC表达并因此触发SRC/Ras/ERK途径的抑制。这些结果表明DADS可能是一种有前途的乳腺癌抗癌药物。miR-34 a也可能是一种潜在的基因治疗剂，可以增强DADS的抗肿瘤作用。
Diallyl disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.
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影响因子：
8
作者：
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通讯作者：
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影响因子：
64.8
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DOI：
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