Coming to terms with fear
Coming to terms with fear
复制标题
DOI：
10.1073/pnas.1400335111
复制
发表时间：
2014-02-25
影响因子：
11.1
通讯作者：
LeDoux, Joseph E.
中科院分区：
文献类型：
--
作者：
LeDoux, Joseph E.
恐惧的大脑机制已经使用巴甫洛夫恐惧条件反射进行了广泛的研究，这是一种允许探索大脑如何学习并随后检测和应对威胁的程序。然而，发现和应对威胁的机制与引起有意识恐惧的机制不同。这是一个重要的区别，因为基于有意识和无意识过程的症状可能容易受到不同的诱发因素的影响，并且对于患有不受控制的恐惧或焦虑的人也可以采用不同的方法进行治疗。一个所谓的恐惧条件反射的概念，在电路无意识地运作，但间接地有助于有意识的恐惧，提出了前进的方向。
The brain mechanisms of fear have been studied extensively using Pavlovian fear conditioning, a procedure that allows exploration of how the brain learns about and later detects and responds to threats. However, mechanisms that detect and respond to threats are not the same as those that give rise to conscious fear. This is an important distinction because symptoms based on conscious and nonconscious processes may be vulnerable to different predisposing factors and may also be treatable with different approaches in people who suffer from uncontrolled fear or anxiety. A conception of so-called fear conditioning in terms of circuits that operate nonconsciously, but that indirectly contribute to conscious fear, is proposed as way forward.