Induction of apoptosis by paclitaxel in human oral carcinoma cells
Induction of apoptosis by paclitaxel in human oral carcinoma cells
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DOI：
10.1016/j.ijom.2006.01.011
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发表时间：
2006-07-01
影响因子：
2.4
通讯作者：
Inokuchi, T.
中科院分区：
文献类型：
--
作者：
Nonaka, M.;Ikeda, H.;Inokuchi, T.
本研究探讨了紫杉醇诱导NB-1口腔癌细胞凋亡以及Bcl-2和Bax的表达与凋亡细胞死亡的关系。紫杉醇以剂量和时间依赖性方式诱导NB-1细胞凋亡。紫杉醇可诱导NB-1细胞凋亡，其机制可能与下调Bcl-2和上调Bax有关。
The present study investigated induction of apoptosis in NB-1 oral carcinoma cells by paclitaxel and the expression of Bcl-2 and Bax in relation to this apoptotic cell death. Paclitaxel induced apoptotic cell death in NB-1 cells in a dose-and a time-dependent manner. The present results suggest that paclitaxel can induce apoptosis of NB-1 cells, which may be mediated by down-regulation of Bcl-2 together with up-regulation of Bax.