BIOCHEMICAL EVENTS IN DELAYED NEUROTOXICITY - IS AGING OF CHYMOTRYPSIN INHIBITED BY SALIGENIN CYCLIC PHOSPHATES A MODEL FOR AGING OF NEUROTOXIC ESTERASE
BIOCHEMICAL EVENTS IN DELAYED NEUROTOXICITY - IS AGING OF CHYMOTRYPSIN INHIBITED BY SALIGENIN CYCLIC PHOSPHATES A MODEL FOR AGING OF NEUROTOXIC ESTERASE
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DOI：
10.1016/0378-4274(80)90154-x
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发表时间：
1980-01-01
影响因子：
3.5
通讯作者：
CLOTHIER, B
中科院分区：
文献类型：
--
作者：
JOHNSON, MK;CLOTHIER, B
胰凝乳蛋白酶和神经毒性酯酶（NTE）有一些相似之处。在用芳基水杨苷元环状磷酸酯抑制浓缩的（80-800 μ M）胰凝乳蛋白酶后，已知发生老化，并且一些酚类物质附着到蛋白质上。这种结合是与任何可用的亲电试剂如Tris、还原型谷胱甘肽或蛋白质的非特异性反应的表现。该反应不是一个模型的100%有效的转移烷基基团的蛋白质，发生在老化的NTE抑制磷酸二烷基酯。
Chymotrypsin and neurotoxic esterase (NTE) have some similarities. After inhibition of concentrated (80-800 .mu.M) chymotrypsin by aryl saligenin cyclic phosphates it is known that aging occurs and some phenolic material becomes attached to protein. This binding was a manifestation of non-specific reaction with any available electrophile such as Tris, reduced glutathione, or protein. The reaction is not a model for the 100% efficient transfer of alkyl groups to protein which occurs during aging of NTE inhibited by dialkyl phosphates.