Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
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DOI：
10.1016/s0006-3223(97)00321-1
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发表时间：
1997-10-01
影响因子：
10.6
通讯作者：
Joyce, JN
中科院分区：
文献类型：
--
作者：
Gurevich, EV;Joyce, JN
先前的研究表明，精神分裂症患者的皮质血清素（5-HT）系统存在紊乱。然而，这些研究因患者群体的自杀而混淆，自杀本身与 5-HT 系统的改变有关。在这项研究中，我们对长期住院的非自杀性精神分裂症患者死后组织中额叶和顶叶皮层 14 个区域中 5-HT 系统的各个组成部分进行了分析，与年龄匹配的对照组进行比较。我们发现对照组和精神分裂症患者在 5-HT 摄取位点的密度或 5-HT 神经支配的其他标志物方面没有差异。在布罗德曼 24 区和 6 区，所有精神分裂症患者的 5-HT2A、C 受体浓度均下降，无论其抗精神病药物治疗史如何。在所有其他检查区域中，服用药物的精神分裂症患者在死亡时的 5-HT2A,C 受体浓度显着降低，而那些在死亡时停止药物的患者则显示出与对照受试者相同的值。精神分裂症患者的 24、9a 区（9 区尾部）、44 和 6 区 5-HT1A 受体密度增加。抗精神病治疗似乎没有显着效果，因此，精神分裂症中 5-HT 系统改变的具体模式可能取决于患者群体和生前抗精神病治疗。这些数据还提供证据表明 5-HT2 受体的调节可能涉及抗精神病作用。 (C) 1997 年生物精神病学协会。
Previous studies have suggested a disturbance in the cortical serotonergic (5-HT) system in schizophrenia; however these studies have been confounded by suicide in the patient groups, which in itself is associated with alterations in the 5-HT system. In this study we characterized various components of the 5-HT system in 14 areas of the frontal and parietal cortex in tissue obtained at postmortem from aged chronically hospitalized nonsuicidal schizophrenics compared to age-matched controls, We found no differences between control and schizophrenic subjects in the density of 5-HT uptake sites or other markers of 5-HT innervation. In Brodmann areas 24 and 6 the concentration of 5-HT2A,C receptors was decreased in all schizophrenics regardless of their antipsychotic treatment history. In all other areas examined 5-HT2A,C receptor concentrations were dramatically decreased in schizophrenic patients on drugs at time of death, whereas those off drugs at death showed the same values as control subjects. The density of 5-HT1A receptors was increased in areas 24, 9a (caudal part of area 9), 44, and 6 in subjects with schizophrenia. Antipsychotic treatment did not appear to have a significant effect, Thus, the specific pattern of alterations in the 5-HT system in schizophrenia may depend on the patient population and on antemortem antipsychotic treatment. These data also provide evidence that regulation of the 5-HT2 receptor may be involved in antipsychotic action. (C) 1997 Society of Biological Psychiatry.