Running with neighbors: coordinating cell migration and cell-cell adhesion.
Running with neighbors: coordinating cell migration and cell-cell adhesion.
复制标题
DOI：
10.1016/j.ceb.2015.07.004
复制
发表时间：
2015-10
影响因子：
7.5
通讯作者：
Nelson WJ
中科院分区：
文献类型：
--
作者：
Collins C;Nelson WJ
许多生物过程都需要大量细胞的协调运动，如原肠形成和伤口愈合。在集体细胞迁移过程中，细胞-细胞和细胞-细胞外基质(ECM)的黏附必须整合，以使细胞与邻近细胞和底物保持强烈的相互作用。细胞-细胞连接和基于整合素的细胞-ECM黏附的启动和维持需要机械信号的整合，肌动蛋白细胞骨架的动态调节，以及包括Rho家族GTP酶在内的特定信号级联的输入。在这里，我们总结了最近在理解在集体细胞迁移过程中基于钙粘附素和整合素的粘连中这些途径之间的相互作用方面取得的进展，并强调了该领域仍然存在的悬而未决的问题。
Coordinated movement of large groups of cells is required for many biological processes, such as gastrulation and wound healing. During collective cell migration, cell-cell and cell-extracellular matrix (ECM) adhesions must be integrated so that cells maintain strong interactions with neighboring cells and the underlying substratum. Initiation and maintenance of cadherin adhesions at cell-cell junctions and integrin-based cell-ECM adhesions require integration of mechanical cues, dynamic regulation of the actin cytoskeleton, and input from specific signaling cascades, including Rho family GTPases. Here, we summarize recent advances made in understanding the interplay between these pathways at cadherin- and integrin-based adhesions during collective cell migration and highlight outstanding questions that remain in the field.