Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer.
Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer.
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DOI：
10.1016/j.trecan.2019.11.008
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发表时间：
2020-01
期刊：
影响因子：
18.4
通讯作者：
S. Nizzero;Haifa Shen;M. Ferrari;B. Corradetti
中科院分区：
文献类型：
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作者：
S. Nizzero;Haifa Shen;M. Ferrari;B. Corradetti
由于旨在增强免疫介导的抗肿瘤反应的策略的成功，免疫肿瘤学获得了动力。免疫转运肿瘤物理学领域研究驱动癌症免疫治疗的物理过程。这篇综述讨论了从物理角度确定基于免疫疗法的治疗结果的三个主要方面：（i）空间，肿瘤块内癌症和免疫细胞的分布，（ii）时间，针对肿瘤的免疫应答的时间动态，以及（iii）活性，免疫细胞群体抑制癌症的能力。在介绍这些主题与文献中的例子，我们详细调查了两种情况下，空间，时间和激活变量之间的相互作用决定免疫反应：纳米树突状细胞疫苗和免疫抑制卵巢癌。
Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.