Tenascin-R distinct domains modulate migration of neural stem/progenitor cells in vitro
Tenascin-R distinct domains modulate migration of neural stem/progenitor cells in vitro
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DOI：
10.1007/s11626-008-9145-6
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发表时间：
2009-02-01
影响因子：
2.1
通讯作者：
Liao, Hong
中科院分区：
文献类型：
--
作者：
Huang, Wenhui;Zhang, Luyong;Liao, Hong
Extracellular matrix (ECM) molecules constitute a "niche" that modulates the migration, proliferation, and differentiation of neural stem/progenitor cells (NSPCs). The glycoprotein Tenascin-R (TN-R) is an ECM molecule, comprising multiple domains. Either the whole TN-R molecule or its distinct domains has been demonstrated to play a very important role in the developing central nervous system. However, little is known about the effect of the TN-R domain on NSPCs, especially NSPC migration. In the present study, we first show that both TN-R domains epidermal growth factor-like repeat (EGFL) and fibronectin type III (FN)6-8 can inhibit the NSPCs migration from neurospheres in vitro. Furthermore, both the EGFL and FN6-8 domains affect the distribution of neurons generated from neurospheres, indicating that EGFL and FN6-8 domains inhibit the motility of neurons generated from neurospheres. These results suggest that TN-R has an inhibitory effect on NSPCs migration.
