NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
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DOI：
10.1523/jneurosci.1692-12.2012
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发表时间：
2012-06-20
期刊：
影响因子：
--
通讯作者：
Hen R
中科院分区：
文献类型：
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作者：
Kheirbek MA;Tannenholz L;Hen R
成年人产生的颗粒细胞（GC）在齿状回（DG）表现出一个时期的高度可塑性有丝分裂后4-6周。然而，这一关键的可塑性窗口对海马神经发生和行为的功能贡献仍然未知。在这里，我们发现，从成人出生的GC中删除含有NR 2B的NMDA受体损害了DG中的LTP的神经发生依赖性形式，降低了成人出生的GC的树突复杂性，但不影响它们的存活。从成年出生的GC中删除含有NR 2B的NMDA受体的小鼠在基线焦虑样行为或对非常不同的环境的辨别方面与对照组没有差异，但在对高度相似的环境的辨别方面受损。这些结果表明，NR 2B依赖的可塑性的成年出生的GC是必要的精细上下文的歧视，是一致的模式分离的建议作用。
Adult generated granule cells (GCs) in the dentate gyrus (DG) exhibit a period of heightened plasticity 4–6 weeks post-mitosis. However, the functional contribution of this critical window of plasticity to hippocampal neurogenesis and behavior remains unknown. Here, we show that deletion of NR2B-containing NMDA receptors from adult born GCs impairs a neurogenesis-dependent form of LTP in the DG, reduces dendritic complexity of adult born GCs, but does not impact their survival. Mice in which the NR2B-containing NMDA receptor was deleted from adult born GCs did not differ from controls in baseline anxiety-like behavior or discrimination of very different contexts, but were impaired in discrimination of highly similar contexts. These results indicate that NR2B-dependent plasticity of adult born GCs is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.