COMPARISON OF LOCALIZED PROTON NMR SIGNALS OF SKELETAL-MUSCLE AND FAT TISSUE INVIVO - 2 LIPID COMPARTMENTS IN MUSCLE-TISSUE
COMPARISON OF LOCALIZED PROTON NMR SIGNALS OF SKELETAL-MUSCLE AND FAT TISSUE INVIVO - 2 LIPID COMPARTMENTS IN MUSCLE-TISSUE
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DOI：
10.1002/mrm.1910290203
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发表时间：
1993-02-01
影响因子：
3.3
通讯作者：
LUTZ, O
中科院分区：
文献类型：
--
作者：
SCHICK, F;EISMANN, B;LUTZ, O
在体内的H-1 NMR光谱的小体积的利益（VOI）定位在人比目鱼肌（8毫升），并与皮下脂肪组织和股骨黄骨髓（2毫升）的体积选择性光谱进行比较。所有检查均采用双自旋回波（PRESS）定位技术进行。为了提供可比性，使用相同的序列定时记录不同组织的光谱。使用> 200 ms的长回波时间TE，肌肉组织脂质信号的分辨率得到了明显提高。肌肉组织的光谱显示出源自两个隔室的脂质信号，其共振频率之差约为0.2 ppm（拉莫尔频率差12-13 Hz，1.5 T）。两个脂肪酸隔室的存在支持的弛豫时间和线形分析的测量。两个隔室均含有组成相似的脂肪酸或甘油三酯。可能一个腔室对应于肌肉组织内的脂肪细胞，另一个具有较低拉莫尔频率的腔室位于肌肉细胞内。
In vivo H-1 NMR spectra of small volumes-of-interest (VOI) were localized in human soleus muscle (8 ml) and compared with volume selective spectra of subcutaneous fat tissue and femoral yellow bone marrow (2 ml). All examinations were performed by the double spin echo (PRESS) localization technique. To provide comparability, spectra of different tissues were recorded using identical sequence timing. Clearly improved resolution of the lipid signals of muscle tissue was obtained using long echo times TE > 200 ms. The spectra of muscle tissue exhibit lipid signals that stem from two compartments with a difference of their resonance frequencies of about 0.2 ppm (Larmor frequency difference 12-13 Hz at 1.5 T). The existence of two fatty acid compartments is supported by measurements of the relaxation times and line shape analysis. Both compartments contain fatty acids or triglycerides with similar composition. Probably one compartment corresponds to fat cells within muscle tissue, the other compartment with lower Larmor frequency is located within muscle cells.