Genetic Interaction between Ribosome Biogenesis and Inositol Polyphosphate Metabolism in Saccharomyces cerevisiae
Genetic Interaction between Ribosome Biogenesis and Inositol Polyphosphate Metabolism in Saccharomyces cerevisiae
复制标题
DOI：
10.1271/bbb.80599
复制
发表时间：
2009-02-01
影响因子：
1.6
通讯作者：
Mizuta, Keiko
中科院分区：
文献类型：
--
作者：
Horigome, Chihiro;Ikeda, Ryo;Mizuta, Keiko
Rrs 1在酿酒酵母60 S核糖体亚基组装中具有重要作用。我们分离了一个温度敏感的kcs 1突变体，它抑制rrs 1 -1的冷敏感性。kcs 1等位基因导致6磷酸肌醇激酶结构域截短，kcs 1破坏抑制60 S核糖体亚基组装中rrs 1 -1的缺陷。这些结果表明，肌醇多磷酸代谢影响酵母核糖体生物合成。
Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.