Pathophysiology of GvHD and Other HSCT-Related Major Complications.
Pathophysiology of GvHD and Other HSCT-Related Major Complications.
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DOI：
10.3389/fimmu.2017.00079
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发表时间：
2017
影响因子：
7.3
通讯作者：
Holler E
中科院分区：
文献类型：
--
作者：
Ghimire S;Weber D;Mavin E;Wang XN;Dickinson AM;Holler E
60多年来，造血干细胞移植一直是几种血液病和遗传性疾病的主要治疗方法，但其疗效受到移植物抗宿主病（GvHD）的继发性疾病的限制。为了提高患者的生活质量，成功的移植已经取得了巨大的进步，然而，完全成功是很难实现的。本文综述了GvHD的病理生理学、GvHD相关并发症的预防和治疗的最新进展，以及GvHD的潜在治疗进展。
For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve patient quality of life, and yet, complete success is hard to achieve. This review assimilates recent updates on pathophysiology of GvHD, prophylaxis and treatment of GvHD-related complications, and advances in the potential treatment of GvHD.