The cell cycle switch computes approximate majority.
The cell cycle switch computes approximate majority.
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DOI：
10.1038/srep00656
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发表时间：
2012
影响因子：
4.6
通讯作者：
Csikasz-Nagy, Attila
中科院分区：
文献类型：
--
作者：
Cardelli, Luca;Csikasz-Nagy, Attila
计算系统和生物系统都必须决定从一个状态转换为“大约多数”计算算法。最初的相对多数。通过与近似多数计算的结构和动力学相关的系统，我们通过确定性，随机和概率的方法研究了这两个开关的行为，并表明这两个系统的稳态和临时动力学相似它们可以作为振荡网络的组成部分交换。
Both computational and biological systems have to make decisions about switching from one state to another. The ‘Approximate Majority’ computational algorithm provides the asymptotically fastest way to reach a common decision by all members of a population between two possible outcomes, where the decision approximately matches the initial relative majority. The network that regulates the mitotic entry of the cell-cycle in eukaryotes also makes a decision before it induces early mitotic processes. Here we show that the switch from inactive to active forms of the mitosis promoting Cyclin Dependent Kinases is driven by a system that is related to both the structure and the dynamics of the Approximate Majority computation. We investigate the behavior of these two switches by deterministic, stochastic and probabilistic methods and show that the steady states and temporal dynamics of the two systems are similar and they are exchangeable as components of oscillatory networks.
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