Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
复制标题
DOI：
10.1016/j.jnutbio.2018.07.007
复制
发表时间：
2018-11-01
影响因子：
5.6
通讯作者：
Stutz, Graciela
中科院分区：
文献类型：
--
作者：
Bianconi, Santiago;Santillan, Maria E.;Stutz, Graciela
ω-3多不饱和脂肪酸（ω-3 PUFA）与胎儿和婴儿的生长和发育有关。目的：评估长期暴露于膳食ω-3多不饱和脂肪酸失衡是否会改变出生前和/或出生后幼崽的发育和以后的生殖功能。小鼠母鼠在受孕前和整个妊娠-哺乳期喂食omega-3 PUFA对照（大豆油，7%）、缺乏（葵花油，7%）或过量（混合油; 4.2%鳕肝+2.8%大豆）饮食，随后，其幼仔从断奶至成年接受相同饮食。后代的躯体，神经生物学和生殖参数进行了评价。与对照组相比，过剩组仔鼠在断奶前体重较轻，出生后7 - 49天身长较短（P
Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are relevant to fetal and infant growth and development. Objective: to assess whether long-term exposure to dietary omega-3 PUFA imbalance alters pre- and/or postnatal pups' development and reproductive function later in life. Mice dams were fed with omega-3 PUFA Control (soybean oil, 7%), Deficient (sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver+2.8% soybean) diet before conception and throughout gestation-lactation and later on, their pups received the same diet from weaning to adulthood. Offspring somatic, neurobiological and reproductive parameters were evaluated. Excess pups were lighter during the preweaning period and shorter in length from postnatal day (PND) 7 to 49, compared to Control pups (P