Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment
Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment
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DOI：
10.1093/ntr/ntp103
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发表时间：
2009-09-01
影响因子：
4.7
通讯作者：
Westman, Eric C.
中科院分区：
文献类型：
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作者：
Rose, Jed E.;Herskovic, Joseph E.;Westman, Eric C.
先前的研究报告称，与在戒烟日期开始的常规治疗相比，在目标戒烟日期之前开始尼古丁皮肤贴剂治疗的戒烟率增加。我们假设，在尼古丁持续水平存在的情况下吸烟会减弱吸烟的强化作用，并导致对吸入尼古丁的依赖性下降，从而促进戒烟。（每组n = 100）接受尼古丁贴片（21 mg/24 hr）或安慰剂贴剂治疗2周，在此期间，吸烟的香烟品牌或转换为低焦油和尼古丁香烟：2（尼古丁贴片）× 2（香烟类型）析因设计。从戒烟之日起，所有组均接受标准尼古丁贴片治疗，包括6周21 mg/24 hr、2周14 mg/24 hr和2周7 mg/24 hr。戒烟定义为从戒烟之日起自我报告不吸烟，并通过吸入空气中的一氧化碳证实。连续戒烟率约为旋进尼古丁贴片治疗的两倍。根据Fagerstrom尼古丁依赖测试评分，治疗主要使依赖程度较低的吸烟者受益。所有的治疗都有很好的耐受性，鉴于这些发现和以前研究的类似结果，目前尼古丁贴片的标签建议戒烟后才使用尼古丁替代疗法，应该重新检查。
Previous studies have reported that smoking abstinence rates are increased when nicotine skin patch treatment is initiated prior to the target quit smoking date, as compared with conventional treatment beginning on the quit date. We hypothesized that smoking in the presence of continuous levels of nicotine would attenuate the reinforcing effects of cigarette smoking and lead to a decline in dependence on inhaled nicotine, thus facilitating cessation.This study involved four groups of smokers (n = 100 per group) who received either nicotine patch (21 mg/24 hr) or placebo patch treatment for 2 weeks before the quit smoking date, and during this period, smoked their usual brands of cigarettes or switched to low-tar and nicotine cigarettes: a 2 (nicotine patch) x 2 (cigarette type) factorial design. From the quit date on, all groups received standard nicotine patch treatment, consisting of 6 weeks of 21 mg/24 hr, 2 weeks of 14 mg/24 hr, and 2 weeks of 7 mg/24 hr. Abstinence was defined as self-report of no smoking from the quit date on, confirmed by expired-air carbon monoxide.Continuous abstinence rates were approximately doubled by precessation nicotine patch treatment. The treatment mainly benefited smokers with lower levels of dependence, based on Fagerstrom Test for Nicotine Dependence score. All treatments were well tolerated.In view of these findings and similar results from previous studies, current labeling of the nicotine patch, which recommends using nicotine replacement therapy only after the quit date, should be reexamined.