Tyrosine phosphorylation: thirty years and counting.
Tyrosine phosphorylation: thirty years and counting.
复制标题
DOI：
10.1016/j.ceb.2009.01.028
复制
发表时间：
2009-04
影响因子：
7.5
通讯作者：
Hunter T
中科院分区：
文献类型：
--
作者：
Hunter T
酪氨酸磷酸化自发现以来的30多年来，已成为所有真核细胞信号转导和调控的重要机制，控制着细胞增殖、细胞周期进程、代谢稳态、转录激活、神经传递、分化发育和衰老等许多过程。酪氨酸磷酸化的扰动是许多人类疾病，特别是癌症的基础，这促使了与疾病有关的酪氨酸激酶抑制剂的发展，其中一些已被批准用于临床使用。以下是我个人对过去30年来一些显著发现的简要反思，这些发现导致了酪氨酸激酶抑制剂用于疾病治疗的发展。
In the 30 years since its discovery, tyrosine phosphorylation has emerged as a fundamentally important mechanism of signal transduction and regulation in all eukaryotic cells, governing many processes, including cell proliferation, cell cycle progression, metabolic homeostasis, transcriptional activation, neural transmission, differentiation and development, and aging. Perturbations in tyrosine phosphorylation underlie many human diseases, and in particular cancer, and this has prompted the development of inhibitors of tyrosine kinases implicated in disease, a number of which have been approved for clinical use. The following is a brief personal reflection on some of the salient findings over the past 30 years that led to the development of tyrosine kinase inhibitors for disease therapy.
登录
查看更多内容
影响因子：
64.5
作者：
Levinson NM;Seeliger MA;Cole PA;Kuriyan J
通讯作者：
Kuriyan J
影响因子：
16
作者：
Hu, JJ;Liu, J;Hubbard, SR
通讯作者：
Hubbard, SR
影响因子：
158.5
作者：
Kobayashi, S;Boggon, TJ;Halmos, B
通讯作者：
Halmos, B
影响因子：
4.4
作者：
Amanchy, R;Kalume, DE;Pandey, A
通讯作者：
Pandey, A
DOI：
10.1073/pnas.0707270105
发表时间：
2008-01-15
影响因子：
11.1
作者：
Guo, Ailan;Villen, Judit;Comb, Michael J.
通讯作者：
Comb, Michael J.