Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking.
Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking.
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DOI：
10.1016/j.addicn.2021.100003
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发表时间：
2022-03-01
期刊：
影响因子：
--
通讯作者：
Li, Chiang-Shan R
中科院分区：
文献类型：
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作者：
Chen, Yu;Chaudhary, Shefali;Li, Chiang-Shan R
包括脑岛和前扣带回(ACC)在内的突起网络与尼古丁成瘾有关。结构成像研究报告了吸烟者与非吸烟者相比脑岛和ACC灰质体积(GMV)的减少。然而，目前尚不清楚脑岛和ACC GMV可能与多年吸烟、成瘾严重程度或已知的使个人容易吸烟的行为特征之间的关系。在这里，利用人类连接组计划的数据集和基于体素的形态计量学，我们复制了在年龄、性别和平均每天饮酒量方面匹配的吸烟者(70例重度吸烟者和209例轻度吸烟者)脑岛和内侧前额叶皮质(包括背侧ACC和辅助运动区(dACC/SMA))较小GMV的研究结果。脑岛GMV或dACC/SMA与吸烟年限或Fagerstrom尼古丁依赖试验(FTND)得分无显著相关性。根据NIH情绪评估，重度吸烟者与从不吸烟的人相比，表现出更高的外化和内化得分。在重度吸烟者中，dACC/SMA与外化和内化得分均呈正相关，而与脑岛GMV无关。这些发现共同证实了重度吸烟者突起网络的体积变化，并表明脑岛和dACC/SMA在慢性吸烟中可能扮演着不同的功能障碍角色。
The salience network, including the insula and anterior cingulate cortex (ACC), has been implicated in nicotine addiction. Structural imaging studies have reported diminished insula and ACC gray matter volumes (GMVs) in smokers as compared to nonsmokers. However, it remains unclear how insula and ACC GMVs may relate to years of smoking, addiction severity, or behavioral traits known to dispose individuals to smoking. Here, with a dataset curated from the Human Connectome Project and voxel-based morphometry, we replicated the findings of smaller GMVs of the insula and medial prefrontal cortex, including the dorsal ACC and supplementary motor area (dACC/SMA), in (70 heavy < 209 light < 209 never) smokers matched in age, sex, and average daily num ber of drinks. The GMVs of the insula or dACC/SMA were not significantly correlated with years of smoking or Fagerstrom Test for Nicotine Dependence (FTND) scores. Heavy relative to never smokers demonstrated higher externalizing and internalizing scores, as evaluated by the NIH Emotion. In heavy smokers, the dACC/SMA but not insula GMV was positively correlated with both externalizing and internalizing scores. The findings together confirm volumetric changes in the salience network in heavy smokers and suggest potentially distinct dysfunctional roles of the insula and dACC/SMA in chronic smoking.