Vasculogenic mimicry is a key prognostic factor for laryngeal squamous cell carcinoma: a new pattern of blood supply
Vasculogenic mimicry is a key prognostic factor for laryngeal squamous cell carcinoma: a new pattern of blood supply
复制标题
血管生成拟态是喉鳞状细胞癌的关键预后因素：一种新的血液供应模式
DOI：
10.3760/cma.j.issn.0366-6999.2012.19.016
复制
发表时间：
2012-10-05
影响因子：
6.1
通讯作者：
Zhang Jin-mei
中科院分区：
文献类型：
--
作者：
Lin Peng;Wang Wei;Zhang Jin-mei
背景复发和局部淋巴结转移影响喉癌患者的预后。为探讨喉鳞状细胞癌中血管生成拟态（vasculogenicmimicry，VM）的临床病理学意义及其对预后的影响，对168例喉鳞状细胞癌（laryngeal squamous cell carcinoma，LSCC）的临床病理资料进行回顾性分析。结果喉鳞癌中VM与淋巴结转移和临床进展有关（P=0.003）。VM与喉鳞癌的组织病理学分级相关（P=0.001）。单变量生存分析显示，VM是疾病特异性生存（P=0.039）和无转移生存（P=0.042）的不良预后因素。多因素生存分析表明，VM是影响喉鳞癌患者生存率的独立预后因素（P=0.003）。喉鳞状细胞癌伴微血管增生更易发生浸润和转移。中华医学杂志2012;125（19）：3445-3449
Background Recurrence and local lymph node metastasis affected the prognosis of patients with laryngeal cancer. The aim of this study was to analyze clinical and pathological significance of vasculogenic mimicry (VM) in laryngeal squamous cell carcinoma (LSCC) and evaluate its contribution to prognosis.Methods Data of 168 cases of LSCC were reviewed retrospectively to reveal clinical pathology and prognostic significance of VM. CD31 and periodic acid-Schiff double staining was used to identify VM.Results VM in LSCC contributed to lymph node metastasis (P=0.003) and clinical progression. VM correlated to histopathology grade (P=0.001) of LSCC. VM was an adverse prognostic factor for both disease-specific survival (P=0.039) and metastasis-free survival (P=0.042) by univariate survival analyses. And it was an independent prognostic factor for only disease-specific survival (P=0.003) by multivariate survival analyses.Conclusions VM existed in LSCC. LSCC with VM has more potential to invasion and metastasis. Chin Med J 2012;125(19):3445-3449