Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice
Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice
复制标题
DOI：
10.1093/gerona/glp068
复制
发表时间：
2009-09-01
影响因子：
5.1
通讯作者：
Brown, Thomas A.
中科院分区：
文献类型：
--
作者：
LeBrasseur, Nathan K.;Schelhorn, Teresa M.;Brown, Thomas A.
本研究的目的是检查短期运动训练、肌肉生长抑制素抑制（PF-354）和运动+ PF-354的影响。所有这些都与车辆控制有关。24月龄小鼠生产性能及代谢指标的研究。在研究结束时，pf -354处理的小鼠表现出显著增加的肌肉重量。表现测量显示，运动+ PF-354增加了跑步机跑步时间和疲劳距离（超过两倍），并增加了习惯性活动。然而，衡量力量的方法并没有什么不同。所有治疗组都显示肌肉疲劳减少了30%以上。代谢测量显示，PF-354组和运动+ PF-354组小鼠的基础代谢率更高，运动组和运动+ PF-354组表现出显著更高的胰岛素敏感性。PF-354与Smad3磷酸化降低和过氧化物酶体增殖激活受体γ辅激活因子-1 α表达增加有关，与运动相似。MuRF-1下降。这些数据表明，运动训练和肌肉生长抑制素阻断相结合可以显著改善老年人的身体功能和全身代谢。
The objective of this study was to examine the effects of short-term exercise training, myostatin inhibition (PF-354), and exercise + PF-354. all relative to a vehicle control. on performance and metabolic measures in 24-month-old mice. At study termination, PF-354-treated mice exhibited significantly greater muscle weights. Performance measures revealed that exercise + PF-354 increased treadmill running time and distance to exhaustion (more than twofold) and increased habitual activity. Measures of strength were not different: however. all treatment groups demonstrated more than 30% reductions in muscle fatigue. Metabolic measures showed that basal metabolic rates were higher in PF-354- and exercise + PF-354-treated mice, and exercise and exercise + PF-354 groups exhibited significantly greater insulin sensitivity. PF-354 was associated with decreased Smad3 phosphorylation and increased peroxisome proliferator-activated receptor gamma coactivator-1 alpha expression and, similar to exercise. decreased MuRF-1. The data suggest that the combination of exercise training and myostatin blockade may significantly improve physical function and whole-body metabolism in older individuals.