Performance enhancement strategies for surface plasmon resonance sensors in direct glucose detection using pristine and modified UiO-66: effects of morphology, immobilization technique, and signal amplification
Performance enhancement strategies for surface plasmon resonance sensors in direct glucose detection using pristine and modified UiO-66: effects of morphology, immobilization technique, and signal amplification
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使用原始和改良 UiO-66 进行直接葡萄糖检测的表面等离子共振传感器的性能增强策略：形态、固定技术和信号放大的影响
DOI：
10.1039/d1ta08741j
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发表时间：
2022
影响因子：
11.9
通讯作者：
Kaneti Yusuf Valentino
中科院分区：
文献类型：
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作者：
Gumilar Gilang;Henzie Joel;Yuliarto Brian;Patah Aep;Nugraha Nugraha;Iqbal Muhammad;Amin Mohammed A.;Hossain Md. Shariar A.;Yamauchi Yusuke;Kaneti Yusuf Valentino
糖尿病是一种危险的疾病，是由于身体无法正常产生和使用胰岛素，导致血糖水平升高而引起的。最先进的葡萄糖检测技术是基于表面等离子共振 (SPR) 的传感器。然而，由于葡萄糖尺寸小，该技术有一个轻微的缺点。作为一种多孔材料，Zr基UiO-66 MOF通过氢键与葡萄糖具有良好的吸附作用，因此可以用作SPR葡萄糖传感器的受体和活性层，而不需要其他受体，如葡萄糖氧化酶、伴刀豆球蛋白A或硼酸基化合物。本研究研究了形态效应、固定技术和信号放大策略，以优化 UiO-66 在 SPR 葡萄糖传感器中的利用。通过优化这些参数，成功开发了在0.01-10 mM浓度范围内检测限为0.0693 mM（S/N = 3）的高性能SPR葡萄糖传感器。此外，选择性测试表明，UiO-66/Au基SPR传感器对葡萄糖表现出高选择性。此外，所开发的SPR传感器在检测人体血清中的葡萄糖方面表现出良好的能力，表明其具有广阔的实际应用潜力。
Diabetes is a dangerous disease caused by the inability of the body to produce and use insulin properly, resulting in an increase in the blood glucose level. The most advanced technology for glucose detection is the surface plasmon resonance (SPR)-based sensor. However, this technology has a slight drawback due to the small size of glucose. As a porous material, Zr-based UiO-66 MOF has good adsorption with glucose via hydrogen bonding, so it can be utilized as a receptor and active layer for the SPR glucose sensor, without the need for other receptors, such as glucose oxidase, concanavalin A, or boronic acid-based compounds. This study investigates the morphology effect, immobilization techniques, and signal amplification strategies for optimizing the utilization of UiO-66 in the SPR glucose sensor. By optimizing these parameters, a high-performance SPR glucose sensor with a detection limit of 0.0693 mM (S/N = 3) in the concentration range of 0.01–10 mM is successfully developed. In addition, a selectivity test reveals that the UiO-66/Au-based SPR sensor exhibits a high selectivity toward glucose. Furthermore, the developed SPR sensor showed a good ability in detecting glucose in human blood serum, suggesting its promising potential for practical applications.