Indocyanine Green: Historical Context, Current Applications, and Future Considerations
Indocyanine Green: Historical Context, Current Applications, and Future Considerations
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DOI：
10.1177/1553350615604053
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发表时间：
2016-04-01
影响因子：
1.5
通讯作者：
Augenstein, Vedra A.
中科院分区：
文献类型：
--
作者：
Reinhart, Michaela B.;Huntington, Ciara R.;Augenstein, Vedra A.
背景吲哚菁绿色（ICG）是一种自20世纪50年代中期以来用于心脏病学、眼科学和神经外科学中各种应用的药物染料;然而，其荧光特性仅在最近才用于组织灌注的术中评价。法对ICG在医学领域的表征和应用进行了文献综述。对导航卫星委员会的历史和现状进行了审查，同时还审议了对其今后使用的影响。结果ICG是一种相对无毒、不稳定的化合物，在血管内空间中与白蛋白结合，直至被肝脏快速清除。它在肝脏、心脏和眼科研究中有着广泛的应用，在癌症分期中用于分析组织灌注和识别前哨淋巴结也越来越受欢迎。结论. ICG有无数的应用，对患者的风险很低。它的历史用途有助于医学知识，现在正在研究量化组织灌注，提供靶向治疗，以及术中识别神经血管解剖结构，眼科结构和前哨淋巴结。ICG的新应用可能会减少术后伤口相关并发症，更有效的眼科手术，以及更好地检测和治疗癌细胞。
Background. Indocyanine green (ICG) is a dye used in medicine since the mid-1950s for a variety of applications in in cardiology, ophthalmology, and neurosurgery; however, its fluorescent properties have only recently been used in the intraoperative evaluation of tissue perfusion. Method. A literature review was conducted on the characterization and employment of ICG within the medical field. Historical and current context of ICG was examined while also considering implications for its future use. Results. ICG is a relatively nontoxic, unstable compound bound by albumin in the intravascular space until rapid clearance by the liver. It has widespread uses in hepatic, cardiac, and ophthalmologic studies, and its use in analyzing tissue perfusion and identifying sentinel lymph nodes in cancer staging is gaining popularity. Conclusions. ICG has myriad applications and poses low risk to the patient. Its historical uses have contributed to medical knowledge, and it is now undergoing investigation for quantifying tissue perfusion, providing targeted therapies, and intraoperative identification of neurovascular anatomy, ophthalmic structures, and sentinel lymph nodes. New applications of ICG may lead to reduction in postoperative wound-related complications, more effective ophthalmologic procedures, and better detection and treatment of cancer cells.